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Article

Rapid detection of rifampin-resistant clinical isolates of Mycobacterium tuberculosis by reverse dot blot hybridization.

Biomedical and environmental sciences : BES - 1 Jan 2015

Guo Qian, Yu Yan, Zhu Yan Ling, Zhao Xiu Qin, Liu Zhi Guang, Zhang Yuan Yuan, Li Gui Lian, Wei Jian Hao, Wu Yi Mou, Wan Kang Lin

Abstract excerpt

OBJECTIVE: A PCR-reverse dot blot hybridization (RDBH) assay was developed for rapid detection of rpoB gene mutations in 'hot mutation region' of Mycobacterium tuberculosis (M. tuberculosis). METHODS: 12 oligonucleotide probes based on the wild-type and mutant genotype rpoB sequences of M. tuberculosis were designed to screen the most frequent wild-type and mutant genotypes for diagnosing RIF resistance. 300 M....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25566860
DOI: 10.3967/bes2015.003

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DST

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