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Article

FLCN-mutated eosinophilic renal tumors: clinicopathologic and molecular analysis of five cases highlighting morphologic heterogeneity.

Virchows Archiv : an international journal of pathology - 1 Feb 2026

Zhao Ming, Song Jing, Xu Jiayun, Ru Guoqing, Ye Lin, Zhang Huizhi, Wang Suying

Abstract excerpt

Eosinophilic/oncocytic renal cell neoplasms represent a diagnostically challenging group of tumors with overlapping morphologic and immunophenotypic features. Recent advances in molecular genetics have expanded the spectrum of FLCN-mutated renal tumors, including both Birt-Hogg-Dubé (BHD) syndrome-associated and sporadic cases. This study aimed to characterize the clinicopathologic and molecular features of five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41162600
DOI: 10.1007/s00428-025-04289-x

Genes

FLCN
GPNMB
MTOR
FH
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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