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Article

Renal tumors harboring FLCN mutations: Case series from clinical practice.

Human pathology - 1 Jul 2026

Ding Chien-Kuang C, Chan Emily, Lotan Tamara L, Hang Jen-Fan, Greenland Nancy Y, Stohr Bradley A, Simko Jeffry P, Sirohi Deepika

Abstract excerpt

BACKGROUND: Renal cell neoplasms with FLCN mutations, classically seen in Birt-Hogg-Dubé (BHD) syndrome typically include oncocytoma, chromophobe RCC, and hybrid oncocytic/chromophobe tumors (HOCT). Recent studies have highlighted FLCN-mutated renal cell carcinomas (RCCs) with unclassified morphologies, raising diagnostic challenges. METHODS: We retrospectively identified renal tumors with FLCN mutations by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42000053
DOI: 10.1016/j.humpath.2026.106122

Genes

FLCN
GPNMB
TFEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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