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Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma

12 May 2023

Abstract excerpt

BACKGROUND: Birt-Hogg-Dubé (BHD) syndrome, caused by germline alteration of folliculin (FLCN) gene, develops hybrid oncocytic/chromophobe tumour (HOCT) and chromophobe renal cell carcinoma (ChRCC), whereas sporadic ChRCC does not harbor FLCN alteration. To date, molecular characteristics of these similar histological types of tumours have been incompletely elucidated. METHODS: To elucidate renal tumourigenesis of...

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PMID: 37182269
DOI: 10.1016/j.ebiom.2023.104596

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