Article
Cancer therapy with a CRISPR-assistant telomerase-activating gene expression system
2018-03-29
Abstract excerpt
Telomerase is silent in most normal somatic cells while active in 90% of tumor cells. Various telomerase activity inhibitors have been developed to treat cancer but all failed due to side effects. Here we acted oppositely to develop a cancer therapy named telomerase-activating gene expression (Tage) by utilizing the telomerase activity in tumor cells. By using CRISPR/Cas9 functions, the Tage system can effectively...
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Identifiers and source
- Literature Corpus work
- d51337d1-1e16-5907-8261-599e56adf476
- DOI
- 10.1101/291302