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Article

Saturated Metabolism of Voriconazole N-Oxidation Resulting in Nonlinearity of Pharmacokinetics of Voriconazole at Clinical Doses.

Biological & pharmaceutical bulletin - 1 Jan 2015

Yamada Takahiro, Mino Yasuaki, Yagi Tatsuya, Naito Takafumi, Kawakami Junichi

Abstract excerpt

Metabolic saturation of voriconazole based on the trough plasma concentrations of voriconazole and its major metabolite N-oxide were evaluated according to CYP2C19 genotypes in 58 Japanese patients receiving voriconazole (median dose; 200 mg twice daily) for prophylaxis or treatment. Predose trough plasma concentrations of voriconazole and N-oxide were monitored on day 5 d or later after initiation of...

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Source

Identifiers

PMID: 26424015
DOI: 10.1248/bpb.b15-00241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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