Article
Relationship Between the CYP2C19 Phenotype Using the Voriconazole-to-Voriconazole N-Oxide Plasma Concentration Ratio and Demographic and Clinical Characteristics of Japanese Patients With Different CYP2C19 Genotypes.
Therapeutic drug monitoring - 1 Oct 2017
Niioka Takenori, Fujishima Naohito, Abumiya Maiko, Yamashita Takaya, Ubukawa Kumi, Nara Miho, Fujishima Masumi, Takahashi Naoto, Miura Masatomo
Abstract excerpt
BACKGROUND: Although voriconazole (VRCZ) is metabolized to VRCZ N-oxide principally by CYP2C19, VRCZ clearance is affected by multiple factors. In this study, we investigated the relationship between the CYP2C19 phenotype using the VRCZ-to-VRCZ N-oxide plasma concentration ratio (VRCZ/N-oxide) and demographic and clinical characteristics of Japanese patients taking VRCZ. METHODS: A total of 65 Japanese patients...
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