Article
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Blood - 16 Jan 2014
Thompson A A Roger, Elks Philip M, Marriott Helen M, Eamsamarng Suttida, Higgins Kathryn R, Lewis Amy, Williams Lynne, Parmar Selina, Shaw Gary, McGrath Emmet E, Formenti Federico, Van Eeden Fredericus J, Kinnula Vuokko L, Pugh Christopher W, Sabroe Ian, Dockrell David H, Chilvers Edwin R, Robbins Peter A, Percy Melanie J, Simon M Celeste, Johnson Randall S, Renshaw Stephen A, Whyte Moira K B, Walmsley Sarah R
Abstract excerpt
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3. HIF-2α has both distinct and overlapping biological roles with HIF-1α and has not previously been studied in the context of neutrophil biology. We investigated the role of HIF-2α in regulating key...
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