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Article

Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements.

PloS one - 1 Jan 2015

Hayes James E, Trynka Gosia, Vijai Joseph, Offit Kenneth, Raychaudhuri Soumya, Klein Robert J

Abstract excerpt

Though numerous polymorphisms have been associated with risk of developing lymphoma, how these variants function to promote tumorigenesis is poorly understood. Here, we report that lymphoma risk SNPs, especially in the non-Hodgkin's lymphoma subtype chronic lymphocytic leukemia, are significantly enriched for co-localization with epigenetic marks of active gene regulation. These enrichments were seen in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Regulatory Elements, Transcriptional

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Identifiers

PMID: 26422229
DOI: 10.1371/journal.pone.0139360
PMCID: PMC4589387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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