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Detection of host cell microprotein impurities in antibody drug products

4 Oct 2024

Abstract excerpt

Chinese hamster ovary (CHO) cells are used to produce almost 90% of therapeutic monoclonal antibodies (mAbs) and antibody fusion proteins (Fc-fusion). The annotation of non-canonical translation events in these cellular factories remains incomplete, limiting our ability to study CHO cell biology and detect host cell protein (HCP) impurities in the final antibody drug product. We utilised ribosome footprint...

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PMID: 39366928
DOI: 10.1038/s41467-024-51870-0

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