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Article

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

The Journal of cell biology - 28 Sept 2015

Bessonnard Sylvain, Mesnard Daniel, Constam Daniel B

Abstract excerpt

The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). This lineage decision is specified in compacted morulae by cell polarization and adhesion acting on the Yes-associated protein in the Hippo signaling pathway, but the regulatory mechanisms are unclear. We show that morula compaction and ICM formation depend on PC7 and the related...

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Identifiers

PMID: 26416966
DOI: 10.1083/jcb.201503042
PMCID: PMC4586756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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