Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.

Development (Cambridge, England) - 1 Jan 2000

Constam D B, Robertson E J

Abstract excerpt

Furin, the mammalian prototype of a family of serine proteases, is required for ventral closure and axial rotation, and formation of the yolk sac vasculature. Here we show additionally that left-sided expression of pitx2 and lefty-2 are also perturbed in Furin-deficient embryos. These tissue abnormalities are preceded by a marked delay in the expansion of the definitive endoderm during gastrulation. Using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Endoderm
Share to Furin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrula

Share to Homeobox Protein PITX2

Share to Paired Box Transcription Factors

Share to Subtilisins

Share to Viscera

Source

Identifiers

PMID: 10603343
DOI: 10.1242/dev.127.2.245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.PMID 10603343Read ↗

Human heart-forming organoids recapitulate early heart and foregut developmentSemantic proximity Read ↗

Lung Endoderm Morphogenesis: Gasping for Form and FunctionSemantic proximity Read ↗

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Semantic proximity Read ↗

Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis.Semantic proximity Read ↗

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.Semantic proximity Read ↗

The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning.Semantic proximity Read ↗

Precardiac organoids form two heart fields via Bmp/Wnt signalingSemantic proximity Read ↗

Function of Rieger syndrome gene in left-right asymmetry and craniofacial development.Semantic proximity Read ↗

Multiple roles for Med12 in vertebrate endoderm development.Semantic proximity Read ↗

Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.Semantic proximity Read ↗

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endodermSemantic proximity Read ↗

The mouse fetal‐placental arterial connection: A paradigm involving the primitive streak and visceral endoderm with implications for human developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.