Article
Genetic markers for prediction of treatment outcomes in ovarian cancer.
The pharmacogenomics journal - 1 Oct 2014
Caiola E, Broggini M, Marabese M
Abstract excerpt
Drug resistance in epithelial ovarian cancer (EOC) limits the efficacy of therapies for this malignancy. This phenomenon might be partially explained by strong inter-individual genomic heterogeneity. Single nucleotide polymorphisms (SNPs) located in specific genes involved in platinum-based drugs inactivation and the metabolism and extrusion of taxanes could be relevant in terms of drugs response prediction. In...
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