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Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer

1 Dec 2004

Abstract excerpt

Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly understood, laboratory studies on cancer cell lines suggest that nucleotide excision repair (NER) is the...

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Advanced biosensing and bioanalysis techniques
Metal complexes synthesis and properties
Trace Elements in Health

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15547660
DOI: 10.3892/ijmm.14.6.959

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