Article
CD33 modulates TREM2: convergence of Alzheimer loci.
Nature neuroscience - 1 Nov 2015
Chan Gail, White Charles C, Winn Phoebe A, Cimpean Maria, Replogle Joseph M, Glick Laura R, Cuerdon Nicole E, Ryan Katie J, Johnson Keith A, Schneider Julie A, Bennett David A, Chibnik Lori B, Sperling Reisa A, Bradshaw Elizabeth M, De Jager Philip L
Abstract excerpt
We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.
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