Article
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.
The FEBS journal - 1 Dec 2015
Dickerman Benjamin K, White Christine L, Kessler Patricia M, Sadler Anthony J, Williams Bryan R G, Sen Ganes C
Abstract excerpt
The murine double-stranded RNA-binding protein termed protein kinase R (PKR)-associated protein X (RAX) and the human homolog, protein activator of PKR (PACT), were originally characterized as activators of PKR. Mice deficient in RAX show reproductive and developmental defects, including reduced body size, craniofacial defects and anterior pituitary hypoplasia. As these defects are not observed in PKR-deficient...
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