Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth arrest-specific 6 regulates thrombin-induced expression of vascular cell adhesion molecule-1 through forkhead box O1 in endothelial cells.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2015

Bertin F R, Lemarié C A, Robins R S, Blostein M D

Abstract excerpt

BACKGROUND: Growth arrest-specific 6 (Gas6)-deficient mice are protected against venous thromboembolism (VTE), suggesting a role for Gas6 in this disorder. We previously demonstrated that Gas6 induces forkhead box O1 (FoxO-1) phosphorylation through the phosphoinositide 3-kinase-Akt pathway. FoxO-1 regulates the expression of vascular cell adhesion molecule-1 (VCAM-1), a molecule that has been implicated in VTE....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Intercellular Signaling Peptides and Proteins

Share to Thrombin

Share to Vascular Cell Adhesion Molecule-1

Share to Venous Thromboembolism

Source

Identifiers

PMID: 26414399
DOI: 10.1111/jth.13156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth arrest-specific 6 regulates thrombin-induced expression of vascular cell adhesion molecule-1 through forkhead box O1 in endothelial cells.PMID 26414399Read ↗

FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms.Semantic proximity Read ↗

Genome-Wide Approaches Reveal Functional Interleukin-4-Inducible STAT6 Binding to the Vascular Cell Adhesion Molecule 1 PromoterSemantic proximity Read ↗

Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.Semantic proximity Read ↗

FOSL1 Controls the Assembly of Endothelial Cells into Capillary Tubes by Direct Repression of αv and β3 Integrin TranscriptionSemantic proximity Read ↗

Gas6 Promotes Inflammatory (CCR2hiCX3CR1lo) Monocyte Recruitment in Venous Thrombosis.Semantic proximity Read ↗

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistanceSemantic proximity Read ↗

Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.Semantic proximity Read ↗

Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells.Semantic proximity Read ↗

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.Semantic proximity Read ↗

Repression of vascular endothelial growth factor expression by the runt-related transcription factor 1 in acute myeloid leukemia.Semantic proximity Read ↗

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.Semantic proximity Read ↗

Regulation of NF-κB-dependent Gene Expression by the POU Domain Transcription Factor Oct-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.