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Article

Evaluation of a two-step iterative resampling procedure for internal validation of genome-wide association studies.

Journal of human genetics - 1 Dec 2015

Kang Guolian, Liu Wei, Cheng Cheng, Wilson Carmen L, Neale Geoffrey, Yang Jun J, Ness Kirsten K, Robison Leslie L, Hudson Melissa M, Srivastava Deo Kumar

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified many common genetic variants associated with complex diseases over the past decade. The 'gold standard' method for validating the top single nucleotide polymorphisms (SNPs) identified in GWAS is to independently replicate the findings in similar or diverse large-scale external cohorts. However, for rare diseases, it can be difficult to find an...

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PMID: 26377241
DOI: 10.1038/jhg.2015.110
PMCID: PMC4859941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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