Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans.

Diabetes/metabolism research and reviews - 1 Mar 2016

Frankl Joseph A, Thearle Marie S, Desmarais Cindy, Bogardus Clifton, Krakoff Jonathan

Abstract excerpt

BACKGROUND: Recent work in Pima Indians, a population with high rates of obesity and type 2 diabetes mellitus (T2DM), demonstrated that human leukocyte antigen haplotype DRB1*02 carriers have an increased acute insulin response and decreased risk for the development of T2DM, implicating loss of self-tolerance in the pathogenesis of T2DM. Advances in genomic sequencing have made T-cell receptor repertoire analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complementarity Determining Regions
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Haplotypes

Share to HLA-DRB1 Chains

Share to Indians, North American

Share to Longitudinal Studies

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 26408818
DOI: 10.1002/dmrr.2720
PMCID: PMC6383518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

T-cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans.PMID 26408818Read ↗

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selectionSemantic proximity Read ↗

Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.Semantic proximity Read ↗

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients.Semantic proximity Read ↗

Genetic control of the human V beta 13.2 T cell repertoire: importance of allelic variation outside the coding regions of the TCRBV13S2 gene.Semantic proximity Read ↗

Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes.Semantic proximity Read ↗

Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans.Semantic proximity Read ↗

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR ConsortiumSemantic proximity Read ↗

Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 HaplotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.