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Polarisation and functional characterisation of hepatocytes derived from human embryonic and mesenchymal stem cells

18 Jun 2015

Abstract excerpt

Adult hepatocytes are polarised with their apical and basolateral membranes separated from neighbouring cells by tight junction proteins. Although efficient differentiation of pluripotent stem cells to hepatocytes has been achieved, the formation of proper polarisation in these cells has not been thoroughly investigated. In the present study, human embryonic stem cells (hESCs) and human mesenchymal stem cells...

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PMID: 26405536
DOI: 10.3892/br.2015.480

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