Article
Role of lysine binding residues in the global folding of the lysC riboswitch.
RNA biology - 1 Jan 2015
Smith-Peter Erich, Lamontagne Anne-Marie, Lafontaine Daniel A
Abstract excerpt
Riboswitches regulate gene expression by rearranging their structure upon metabolite binding. The lysine-sensing lysC riboswitch is a rare example of an RNA aptamer organized around a 5-way helical junction in which ligand binding is performed exclusively through nucleotides located at the junction core. We have probed whether the nucleotides involved in ligand binding play any role in the global folding of the...
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