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Article

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye

24 Sept 2015

Abstract excerpt

Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics...

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PMID: 26402857
DOI: 10.1371/journal.pone.0138958

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