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Article

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.

The Journal of biological chemistry - 21 Jun 2013

Wang Ningning, Zimmerman Keith, Raab Ronald W, McKown Robert L, Hutnik Cindy M L, Talla Venu, Tyler Milton F, Lee Jae K, Laurie Gordon W

Abstract excerpt

Homeostasis is essential for cell survival. However, homeostatic regulation of surface epithelia is poorly understood. The eye surface, lacking the cornified barrier of skin, provides an excellent model. Tears cover the surface of the eye and are deficient in dry eye, the most common eye disease...

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Source

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Identifiers

PMID: 23640897
DOI: 10.1074/jbc.M112.436584
PMCID: PMC3689958

Genes

FOXO3
ATG7
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23640897-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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