Article
T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice.
Disease models & mechanisms - 1 Nov 2015
Oldreive Ceri E, Skowronska Anna, Davies Nicholas J, Parry Helen, Agathanggelou Angelo, Krysov Sergey, Packham Graham, Rudzki Zbigniew, Cronin Laura, Vrzalikova Katerina, Murray Paul, Odintsova Elena, Pratt Guy, Taylor A Malcolm R, Moss Paul, Stankovic Tatjana
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft models suffer from limited duration of tumour cell engraftment coupled with gradual T-cell outgrowth. Thus, a greater understanding of the interaction between CLL and T...
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