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Modeling mouse and human development using organoid cultures

15 Sept 2015

Abstract excerpt

In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D environment, embryonic stem cells (ESCs) self-organize into organoids and acquire the right tissue patterning to develop into several endoderm- and ectoderm-derived tissues, mimicking their in vivo counterparts. Tissue-resident adult stem...

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PMID: 26395140
DOI: 10.1242/dev.118570

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