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The mecA Homolog mecC Confers Resistance against β-Lactams in Staphylococcus aureus Irrespective of the Genetic Strain Background

22 Apr 2014

Abstract excerpt

In staphylococci, methicillin resistance is mediated by mecA-encoded penicillin-binding protein 2a (PBP2a), which has a low affinity for beta-lactams. Recently, a novel PBP2a homolog was described as being encoded by mecC, which shares only 70% similarity to mecA. To prove that mecC is the genetic determinant that confers methicillin resistance in Staphylococcus aureus, a mecC knockout strain was generated. The...

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Antimicrobial Resistance in Staphylococcus
Bacterial biofilms and quorum sensing
Bacterial Genetics and Biotechnology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24752255
DOI: 10.1128/aac.02731-13

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