Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in <i>Trypanosoma cruzi</i> Infection

Abstract excerpt

During experimental infection with Trypanosoma cruzi, mice develop a strong CD8(+) T cell response focused mainly on a few immunodominant peptides encoded in trans-sialidase family genes. Despite the potency of this response, the initial emergence and peak of parasite-specific CD8(+) T cells has been noted to be relatively slow. In this study, we further document this delayed onset of T cell responses to T. cruzi...

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