Article
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2016
Wouters Maartje C A, Komdeur Fenne L, Workel Hagma H, Klip Harry G, Plat Annechien, Kooi Neeltje M, Wisman G Bea A, Mourits Marian J E, Arts Henriette J G, Oonk Maaike H M, Yigit Refika, de Jong Steven, Melief Cornelis J M, Hollema Harry, Duiker Evelien W, Daemen Toos, de Bruyn Marco, Nijman Hans W
Abstract excerpt
PURPOSE: Tumor-infiltrating lymphocytes (TIL) are associated with a better prognosis in high-grade serous ovarian cancer (HGSC). However, it is largely unknown how this prognostic benefit of TIL relates to current standard treatment of surgical resection and (neo-)adjuvant chemotherapy. To address this outstanding issue, we compared TIL infiltration in a unique cohort of patients with advanced-stage HGSC...
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