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Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer

27 Jul 2010

Abstract excerpt

BACKGROUND: Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate genes and pathways contributing to infiltration of cytotoxic T lymphocytes (CTLs) in advanced-stage serous ovarian cancer. METHODS: For this study global gene expression was compared between low TIL...

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PMID: 20664601
DOI: 10.1038/sj.bjc.6605820

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