The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO).

doi:10.3390/ijms241311183

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The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO).

International journal of molecular sciences - 6 Jul 2023

Pizarro David, Romero Ignacio, Pérez-Mies Belén, Redondo Andrés, Caniego-Casas Tamara, Carretero-Barrio Irene, Cristóbal Eva, Gutiérrez-Pecharromán Ana, Santaballa Ana, D'Angelo Emanuela, Hardisson David, Vieites Begoña, Matías-Guiu Xavier, Estévez Purificación, Guerra Eva, Prat Jaime, Poveda Andrés, López-Guerrero José Antonio, Palacios José

Abstract excerpt

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1...

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PMID: 37446361
DOI: 10.3390/ijms241311183
PMCID: PMC10342764

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