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Article

Cis-Regulatory Alterations in FOXP4 Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure.

Cancer research - 15 Jul 2025

Niu Siyuan, Ma Jialing, Liu Shasha, Li Yueping, Yue Xinying, Pan Miaoxin, Song Lina, Wu Yutong, Yang Zifei, Tan Yuqian, Gu Linglong, Wang Chaolong, Chang Jiang

Abstract excerpt

Chronic alcohol exposure is a risk factor for developing esophageal squamous cell carcinoma (ESCC). To identify alcohol-responsive genes involved in esophageal carcinogenesis, we employed mouse models to systematically investigate alterations in cis-regulatory elements in the esophageal epithelium across different ethanol exposure durations. A key exposure duration, 16 weeks of exposure to 20% ethanol,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40228145
DOI: 10.1158/0008-5472.CAN-24-3839

Genes

FOXP4
CYP26B1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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