Article
Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315.
PloS one - 1 Jan 2015
Jeeves Rose E, Marriott Alice A N, Pullan Steven T, Hatch Kim A, Allnutt Jon C, Freire-Martin Irene, Hendon-Dunn Charlotte L, Watson Robert, Witney Adam A, Tyler Richard H, Arnold Catherine, Marsh Philip D, McHugh Timothy D, Bacon Joanna
Abstract excerpt
An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M. tuberculosis population there is a proportion of bacteria that are drug-tolerant; this might be because of pre-existing populations of slow growing/non replicating bacteria that are protected from antibiotic action due...
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