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Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

10 May 2018

Abstract excerpt

Drug resistant tuberculosis is increasing world-wide. Resistance against isoniazid (INH), rifampicin (RIF), or both (multi-drug resistant TB, MDR-TB) is of particular concern, since INH and RIF form part of the standard regimen for TB disease. While it is known that suboptimal treatment can lead to resistance, it remains unclear how host immune responses and antibiotic dynamics within granulomas (sites of...

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PMID: 29746491
DOI: 10.1371/journal.pone.0196322

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