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Article

SNP characteristics and validation success in genome wide association studies.

Human genetics - 1 Feb 2022

Gorlova Olga Y, Xiao Xiangjun, Tsavachidis Spiridon, Amos Christopher I, Gorlov Ivan P

Abstract excerpt

Genome wide association studies (GWASs) have identified tens of thousands of single nucleotide polymorphisms (SNPs) associated with human diseases and characteristics. A significant fraction of GWAS findings can be false positives. The gold standard for true positives is an independent validation. The goal of this study was to identify SNP features associated with validation success. Summary statistics from the...

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Identifiers

PMID: 34981173
DOI: 10.1007/s00439-021-02407-8
PMCID: PMC8855685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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