Article
Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium.
PloS one - 1 Jan 2015
Pedersen Philip Juul, Thomsen Kirsten Brolin, Olander Emma Rie, Hauser Frank, Tejada Maria de los Angeles, Poulsen Kristian Lundgaard, Grubb Soren, Buhl Rikke, Calloe Kirstine, Klaerke Dan Arne
Abstract excerpt
The KCNH2 and KCNE2 genes encode the cardiac voltage-gated K+ channel KV11.1 and its auxiliary β subunit KCNE2. KV11.1 is critical for repolarization of the cardiac action potential. In humans, mutations or drug therapy affecting the KV11.1 channel are associated with prolongation of the QT intervals on the ECG and increased risk of ventricular tachyarrhythmia and sudden cardiac death--conditions known as...
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