Article
A missense mutation in the KCNE4 gene is not predictive of equine anhidrosis.
Animal genetics - 1 Feb 2025
van der Graaf Lexie, Leigh Wesley, Szmatoła Tomasz, Roberts Kelsey, Ryan Stephanie, Brown Briana, Van Buren Samantha, Finno Carrie J, Petersen Jessica L
Abstract excerpt
Anhidrosis is defined as a decreased or absent ability to sweat in response to heat and exercise. In horses, this condition can increase the risk of life-threatening hyperthermia. A prior study has suggested that equine anhidrosis is associated with a missense variant (rs68643109) in the Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4 (KCNE4) gene. This project aimed to validate this association...
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