Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

doi:10.1016/j.pan.2015.08.008

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Article

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000

Balázs Anita, Ruffert Claudia, Hegyi Eszter, Hritz István, Czakó László, Takács Tamás, Szepes Zoltán, Németh Balázs Csaba, Gervain Judit, Izbéki Ferenc, Halász Adrienn, Kelemen Dezső, Szmola Richárd, Novák János, Crai Stefan, Illés Anita, Vincze Áron, Molnár Zsolt, Varga Márta, Bod Barnabás, Farkas Gyula, Sümegi János, Szepes Attila, Dubravcsik Zsolt, Lásztity Natália, Párniczky Andrea, Hamvas József, Andorka Csilla, Veres Gábor, Szentkereszty Zsolt, Rakonczay Zoltán, Maléth József, Sahin-Tóth Miklós, Rosendahl Jonas, Hegyi Péter

Abstract excerpt

BACKGROUND: Pancreatic ductal HCO3(-) secretion is critically dependent on the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and the solute-linked carrier 26 member 6 anion transporter (SLC26A6). Deterioration of HCO3(-) secretion is observed in chronic pancreatitis (CP), and CFTR mutations increase CP risk. Therefore, SLC26A6 is a reasonable candidate for a CP susceptibility gene,...

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PMID: 26372434
DOI: 10.1016/j.pan.2015.08.008

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