Article
Is Low Positive JAK2 V617F Mutation Test Result Clinically Significant?: Multi-Institutional Study.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2016
Wu Xiaojun, Lee Joong Won, Peker Deniz, Spitzer Silvia G, Laser Jordan, Reddy Vishnu V B, Harada Shuko
Abstract excerpt
OBJECTIVES: Acquired somatic mutation Janus kinase 2 (JAK2) V617F is associated with various myeloproliferative neoplasms (MPN). Allele-specific real-time polymerase chain reaction has been widely adopted to detect mutation; however, the utility of low positive results is not well understood. The aim of this study is to investigate the clinical significance of low positivity of JAK2 V617F. MATERIALS AND METHODS:...
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