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Article

The relevance of a low JAK2V617F allele burden in clinical practice: a monocentric study.

Oncotarget - 6 Jun 2017

Perricone Margherita, Polverelli Nicola, Martinelli Giovanni, Catani Lucia, Ottaviani Emanuela, Zuffa Elisa, Franchini Eugenia, Dizdari Arbana, Forte Dorian, Sabattini Elena, Cavo Michele, Vianelli Nicola, Palandri Francesca

Abstract excerpt

Since low JAK2V617F allele burden (AB) has been detected also in healthy subjects, its clinical interpretation may be challenging in patients with chronic myeloproliferative neoplasms (MPNs). We tested 1087 subjects for JAK2V617F mutation on suspicion of hematological malignancy. Only 497 (45.7%) patients were positive. Here we present clinical and laboratory parameters of a cohort of 35/497 patients with an AB ≤...

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Identifiers

PMID: 28422729
DOI: 10.18632/oncotarget.16744
PMCID: PMC5514906

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