Article
Molecular diagnosis of the myeloproliferative neoplasms: UK guidelines for the detection of JAK2 V617F and other relevant mutations.
British journal of haematology - 1 Jan 2013
Bench Anthony J, White Helen E, Foroni Letizia, Godfrey Anna L, Gerrard Gareth, Akiki Susanna, Awan Abida, Carter Ian, Goday-Fernandez Andrea, Langabeer Stephen E, Clench Tim, Clark Jordan, Evans Paul A, Grimwade David, Schuh Anna, McMullin Mary F, Green Anthony R, Harrison Claire N, Cross Nicholas C P
Abstract excerpt
Molecular genetic assays for the detection of the JAK2 V617F (c.1849G>T) and other pathogenetic mutations within JAK2 exon 12 and MPL exon 10 are part of the routine diagnostic workup for patients presenting with erythrocytosis, thrombocytosis or otherwise suspected to have a myeloproliferative neoplasm. A wide choice of techniques are available for the detection of these mutations, leading to potential...
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