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Article

Effect of Hepatitis C Virus Genotype 1b Core and NS5A Mutations on Response to Peginterferon Plus Ribavirin Combination Therapy.

International journal of molecular sciences - 7 Sept 2015

Nakamoto Shingo, Imazeki Fumio, Arai Makoto, Yasui Shin, Nakamura Masato, Haga Yuki, Sasaki Reina, Kanda Tatsuo, Shirasawa Hiroshi, Yokosuka Osamu

Abstract excerpt

We examined whether hepatitis C virus (HCV) genotype 1b core- and NS5A-region mutations are associated with response to peginterferon α-2b plus ribavirin combination therapy. A total of 103 patients with high HCV genotype 1b viral loads (≥ 100 KIU/mL) were treated with the combination therapy. Pretreatment mutations in the core region and interferon sensitivity determining region (ISDR) in the NS5A region were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26370958
DOI: 10.3390/ijms160921177
PMCID: PMC4613248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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