Article
Role of hepatitis C virus substitutions and interleukin-28B polymorphism on response to peginterferon plus ribavirin in a prospective study of response-guided therapy.
Journal of viral hepatitis - 1 Nov 2013
Liang C-M, Hu T-H, Lu S-N, Hung C-H, Huang C-M, Wang J-H, Yen Y-H, Chen C-H, Chang K-C, Tsai M-C, Kuo Y-H, Lee C-M
Abstract excerpt
Recent studies have indicated that amino acid (aa) substitutions in the core region and NS5A interferon sensitivity-determining region (ISDR) of hepatitis C virus (HCV) as well as genetic polymorphisms in the interleukin-28B (IL-28B) locus affect the outcome of interferon (IFN)-based therapies. We aimed to investigate the role of these factors on response to peginterferon plus ribavirin in a prospective study of...
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