Article
Role of the Atg9a gene in intrauterine growth and survival of fetal mice.
Reproductive biology - 1 Sept 2015
Kojima Takashi, Yamada Takahiro, Akaishi Rina, Furuta Itsuko, Saitoh Tatsuya, Nakabayashi Kazuhiko, Nakayama Keiichi I, Nakayama Keiko, Akira Shizuo, Minakami Hisanori
Abstract excerpt
Autophagy is activated by environment unfavorable for survival and requires Atg9a protein. Mice heterozygous for p57(Kip2), devoid of the imprinted paternal allele (p57(Kip2+/-)), are known to develop hypertension during pregnancy. To determine whether fetal Atg9a is involved in the intrauterine survival and growth of fetal mice, this study was performed on Atg9a heterozygous (Atg9a(+/-)) pregnant mice with and...
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