Article
Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP.
Molecular and cellular biology - 1 Oct 2005
Zekri Latifa, Chebli Karim, Tourrière Hélène, Nielsen Finn C, Hansen Thomas V O, Rami Abdelhaq, Tazi Jamal
Abstract excerpt
The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the RasGAP-associated endoribonuclease (G3BP)-encoding gene leads to embryonic lethality and growth retardation. G3BP-/- mice that survived to term exhibited increased apoptotic cell death in the central nervous system and neonatal...
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