Article
AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo.
Scientific reports - 15 Sept 2015
Wang Xiaowen, Li Kai, Liu Ling, Shi Qiong, Song Pu, Jian Zhe, Guo Sen, Wang Gang, Li Chunying, Gao Tianwen
Abstract excerpt
Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified the T allele of AHR -129C > T variant as a protective factor against vitiligo. However, biological characterization...
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