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The Autophagic Route of E-Cadherin and Cell Adhesion Molecules in Cancer Progression

16 Dec 2021

Abstract excerpt

Cell-to-cell adhesion is a key element in epithelial tissue integrity and homeostasis during embryogenesis, response to damage, and differentiation. Loss of cell adhesion and gain of mesenchymal features, a phenomenon known as epithelial to mesenchymal transition (EMT), are essential steps in cancer progression. Interestingly, downregulation or degradation by endocytosis of epithelial adhesion molecules (e.g.,...

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PMID: 34944948
DOI: 10.3390/cancers13246328

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