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Article

Acute opioid administration induces hypothalamic-pituitary-adrenal activation and is mediated by genetic variation in interleukin (Il)1B.

Pharmacology, biochemistry, and behavior - 1 Nov 2015

Kershaw Stephanie G, Della Vedova Chris B, Majumder Irina, Ward Michael B, Farquharson Aaron L, Williamson Paul A, White Jason M

Abstract excerpt

There is a complex relationship between drug dependence and stress, with alcohol and other drugs of abuse both relieving stress and potentially inducing physiological stress responses in the user. Opioid drugs have been shown to modulate hypothalamic-pituitary-adrenal (HPA) activity in animal models and individual response to this modulation may play a role in continuation of drug use. Healthy young Caucasian...

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Source

Identifiers

PMID: 26363312
DOI: 10.1016/j.pbb.2015.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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