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Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in <i>Drosophila melanogaster</i> euchromatin

2025-04-25

Abstract excerpt

The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the effect of the length of long-reads on automated variant callers is not well understood, especially for non-human species. Here we show that only ultra-long long-reads, with read N50s greater than 50kb, are capable of acc...

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Literature Corpus work
dc4d5117-f04b-5113-95ef-8f5a3dbefc06
DOI
10.1101/2025.04.21.649852
Open publication

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Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in <i>Drosophila melanogaster</i> euchromatinDOI 10.1101/2025.04.21.649852
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