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Article

Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.

Nature communications - 25 Oct 2019

Chakraborty Mahul, Emerson J J, Macdonald Stuart J, Long Anthony D

Abstract excerpt

It has been hypothesized that individually-rare hidden structural variants (SVs) could account for a significant fraction of variation in complex traits. Here we identified more than 20,000 euchromatic SVs from 14 Drosophila melanogaster genome assemblies, of which ~40% are invisible to high specificity short-read genotyping approaches. SVs are common, with 31.5% of diploid individuals harboring a SV in genes...

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Identifiers

PMID: 31653862
DOI: 10.1038/s41467-019-12884-1
PMCID: PMC6814777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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