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Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2024

Chen Ying-Rong, Yu Xiang, Xu Li-Min, Mei Jue, Tian Meng-Li, Xu Min, Jin Qiu-Yue, Ye Li-Bing, Yang Shui-Xin

Abstract excerpt

Gefitinib is the first-generation drug of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) metabolised by the cytochrome P450 and transported by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). In the present study, the pharmacokinetics of gefitinib in healthy Chinese volunteers was investigated and the effect of genetic polymorphisms on its variability was...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38085693
DOI: 10.1080/00498254.2023.2294039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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